The Bible verse Mark 3:21 in the King James Version reads, "And when his friends heard of it, they went out to lay hold on him: for they said, He is beside himself." This verse is part of a larger passage in the Gospel of Mark that conveys the growing opposition and misunderstanding that Jesus faced during his ministry. In this particular instance, Jesus is in the midst of his public ministry, performing miracles and teaching with authority, which has caused his family and friends to become concerned for his well-being.

The context of Mark 3:21 is important for understanding its deeper meaning. In the preceding verses, Jesus is accused by the scribes of casting out demons by the power of Beelzebub, the prince of demons. This accusation is a clear indication of the hostility and opposition that Jesus faced from some religious leaders. In response to this accusation, Jesus explains the absurdity of Satan casting out Satan and warns about blaspheming against the Holy Spirit. As a result of these events, Jesus' family and friends are worried about his mental and physical well-being, leading them to seek him out and attempt to "lay hold on him."

One of the key themes in Mark 3:21 is the misunderstanding and rejection of Jesus' ministry, particularly by those who are closest to him. The phrase "He is beside himself" used by his friends reflects their concern that Jesus has become mentally unstable or has lost touch with reality. This reveals the lack of understanding and faith in Jesus' identity and mission, even from those who should have known him best. This theme is echoed throughout the Gospel of Mark, as Jesus is repeatedly misunderstood and rejected by various groups, including his own disciples and the religious establishment.

Another important theme in this verse is the cost of discipleship. Jesus' commitment to his mission and his unwavering obedience to the will of God led to misunderstandings and rejection even from those who were closest to him. This serves as a reminder to Jesus' followers that discipleship may come with its own challenges and sacrifices, including the rejection and misunderstanding of family and friends.

Symbolism in this verse can be seen in the actions of Jesus' family and friends. Their attempt to "lay hold on him" can be seen as symbolic of their desire to control or contain Jesus, to prevent him from continuing his radical and controversial ministry. This action reflects the broader societal and cultural context in which Jesus lived, where individuals were expected to adhere to social norms and familial expectations. Jesus' refusal to conform to these expectations and his commitment to the kingdom of God resulted in tension and conflict with those around him.

In summary, Mark 3:21 in the King James Version is a significant verse that highlights the misunderstandings and rejection that Jesus faced, even from those who were closest to him. This verse invites readers to reflect on the cost of discipleship and the challenges that come with following Jesus. It also serves as a reminder of the radical and transformative nature of Jesus' ministry, which often clashed with societal and cultural expectations. Ultimately, this passage invites us to consider our own response to Jesus and the potential cost of following him wholeheartedly.