The verse Daniel 2:21 in the King James Version (KJV) of the Bible reads, "And he changeth the times and the seasons: he removeth kings, and setteth up kings: he giveth wisdom unto the wise, and knowledge to them that know understanding."

This verse is found in the book of Daniel, which is one of the major prophetical books in the Old Testament. The book of Daniel is set during the Babylonian exile and follows the story of Daniel, a young Jewish man who is taken captive and brought to Babylon. Throughout the book, Daniel demonstrates his unwavering faith and commitment to God, even in the face of great adversity and persecution.

In the larger context of the passage, this verse is part of a prayer of thanksgiving and praise to God that Daniel offers after God reveals the forgotten dream and its interpretation to him. In the dream, God revealed to King Nebuchadnezzar a vision of a great statue, which Daniel interprets to represent the rise and fall of kingdoms and empires throughout history.

The verse itself contains profound truths about the sovereignty of God and His ultimate control over the affairs of the world. The verse begins with the assertion that God "changeth the times and the seasons." This speaks to God's authority over the rise and fall of nations and the unfolding of history. It acknowledges that God is ultimately in control of the ebb and flow of human events, and nothing happens outside of His sovereign will.

The verse goes on to declare that God "removeth kings, and setteth up kings." This is a powerful reminder that God is the ultimate authority over the rulers of the earth. Throughout history, we see God's hand at work in the rise and fall of empires and the appointment and removal of kings and leaders. This truth provides comfort to believers, knowing that ultimately, the course of human history is subject to God's divine plan.

The verse also states that God "giveth wisdom unto the wise, and knowledge to them that know understanding." This speaks to the idea that all wisdom and knowledge ultimately come from God. It is a reminder that human wisdom and understanding are ultimately derived from God's revelation and wisdom. This is particularly meaningful in light of the context of the verse, as Daniel's wisdom and understanding come directly from God, enabling him to interpret the king's dream and thereby saving the lives of himself and his friends.

The themes present in this verse include the sovereignty of God, the providence of God, and the wisdom of God. These themes are woven throughout the entire book of Daniel, as Daniel and his companions face various trials and tribulations, yet remain steadfast in their faith. The verse also emphasizes the importance of seeking and receiving wisdom and knowledge from God, rather than relying on human understanding alone.

Symbolically, this verse serves as a powerful reminder of God's ultimate authority and control over the affairs of the world. It encourages believers to trust in God's sovereignty and seek wisdom and understanding from Him. This verse also underscores the importance of recognizing and acknowledging God as the ultimate source of all wisdom and knowledge.

In conclusion, Daniel 2:21 in the King James Version of the Bible is a powerful declaration of God's sovereignty, providence, and wisdom. It reminds believers that God is ultimately in control of the rise and fall of nations and leaders, and that all wisdom and understanding come from Him. This verse offers profound comfort and confidence in the unchanging and all-powerful nature of God.